Huntington’s Disease Essay -- Health Medical Medicine Essays

Huntingtons DiseaseHuntingtons indisposition is a dim inherited disorder characterized by slow gradual personality changes, dementia, and choreiform movements. It is a progressive unhealthiness its average onset is thirty to 40 age of age, and the duration of the disease is about ten to twenty years with end as the outcome. It is known that for Huntingtons disease, there is a corruption of cholinergic and GABAergic neurons in the basal ganglia and the cerebral cortex. The etiology of nerve cellular telephone destruction in Huntingtons disease is unknown. However, there is a late guesswork implicating defects in mitochondrial energy metabolism as the pathology of Huntingtons disease. Huntingtons disease is an autosomal dominant disease. The genetic defect appears on the slight weapon system of the chromosome 4, and it is an extended repetition of the three nucleotide bases (cytosine, adenine, and guanine CAG) that reckon for the aminic acid glutamate. This disease affe cts men and women equally, and it usually appears after the individuals birth marital and had children. The children of an affected p arent have a 50% opportunity of get the disease. With the discovery of the defective gene, it is now possible to have an straight diagnosing before the onset of the disease. The early indications of Huntingtons disease are non prominent the individuals become absentminded, easily irritated, and constantly depressed. Their memory is diminished, and they miss spontaneity, initiative, and the cleverness to concentrate. There are also early subtle signs of choreiform (dance-like) movements. The persons unhorse with piano-playing movements of the fingers or with slight facial twitching (Martin, 1984). The movements gradually become much uncontrollable. ... ...s? Trends in Neurological Sciences, 16 (4) pp. 125-131. Choi, Dennis W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, pp.623-632. Prim, D. M., Simpson, J., Uhle r, T. A., Short, M. P., Bossi, S. R., Breakefield, X. O., & Isacson, O. (1993). Striatal degeneration induced by mitochondrial break is prevented by biologically delivered NGF. Journal of Neuroscience investigate, 35 pp. 452-458. Martin, Joseph B. (1984). Huntingtons disease sore approaches to an old problem. Neurology, 34 pp. 1059-1071. Willard, Frank H. (1993). Medical Neuroanatomy A Problem- orientated manual of arms with Annotated Atlas. Philadelphia J. B. Lippincott Company. Young, Anne B. (1993). Role of excitotoxins in heredito-degenerative neurologic diseases. Research Publications- Association for Research in Nervous and Mental Diseases, 71 pp. 175-189. Huntingtons Disease Essay -- health Medical Medicine EssaysHuntingtons DiseaseHuntingtons disease is a fatal inherited disorder characterized by slow gradual personality changes, dementia, and choreiform movements. It is a progressive disease its average onset is thirty to forty years of age, and the du ration of the disease is about ten to twenty years with death as the outcome. It is known that for Huntingtons disease, there is a degeneration of cholinergic and GABAergic neurons in the basal ganglia and the cerebral cortex. The etiology of nerve cell death in Huntingtons disease is unknown. However, there is a recent hypothesis implicating defects in mitochondrial energy metabolism as the pathology of Huntingtons disease. Huntingtons disease is an autosomal dominant disease. The genetic defect appears on the short arm of the chromosome 4, and it is an extended repetition of the three nucleotide bases (cytosine, adenine, and guanine CAG) that code for the amino acid glutamate. This disease affects men and women equally, and it usually appears after the individuals have married and had children. The children of an affected parent have a 50% chance of inheriting the disease. With the discovery of the defective gene, it is now possible to have an accurate diagnosis before the onset o f the disease. The early indications of Huntingtons disease are not prominent the individuals become absentminded, easily irritated, and constantly depressed. Their memory is diminished, and they lack spontaneity, initiative, and the ability to concentrate. There are also early subtle signs of choreiform (dance-like) movements. The persons begin with piano-playing movements of the fingers or with slight facial twitching (Martin, 1984). The movements gradually become more uncontrollable. ... ...s? Trends in Neurological Sciences, 16 (4) pp. 125-131. Choi, Dennis W. (1988). Glutamate neurotoxicity and diseases of the nervous system. Neuron, pp.623-632. Prim, D. M., Simpson, J., Uhler, T. A., Short, M. P., Bossi, S. R., Breakefield, X. O., & Isacson, O. (1993). Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF. Journal of Neuroscience Research, 35 pp. 452-458. Martin, Joseph B. (1984). Huntingtons disease New approaches to an old proble m. Neurology, 34 pp. 1059-1071. Willard, Frank H. (1993). Medical Neuroanatomy A Problem- Oriented Manual with Annotated Atlas. Philadelphia J. B. Lippincott Company. Young, Anne B. (1993). Role of excitotoxins in heredito-degenerative neurologic diseases. Research Publications- Association for Research in Nervous and Mental Diseases, 71 pp. 175-189.